Platelet-Mediated Modulation of Adaptive Immunity: Unique Delivery of CD154 Signal by Platelet-Derived Membrane Vesicles Short Title: PDMV deliver CD154 signals to B cells
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چکیده
Short Title: PDMV deliver CD154 signals to B cells Daniel L. Sprague, Bennett D. Elzey, Scott A. Crist, Thomas J. Waldschmidt, Robert J. Jensen, and Timothy L. Ratliff Department of Urology, University of Iowa Medical Scientist Training Program, University of Iowa Department of Microbiology, University of Iowa Department of Pathology, University of Iowa Interdisciplinary Immunology Program, University of Iowa Purdue Cancer Center, Purdue University
منابع مشابه
Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles.
Although mounting evidence indicates that platelets participate in the modulation of both innate and adaptive immunity, the mechanisms by which platelets exert these effects have not been clearly defined. The study reported herein uses a previously documented adoptive transfer model to investigate the ability of platelet-derived membrane vesicles to communicate activation signals to the B-cell ...
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The CD154-CD40-mediated costimulatory pathway is critical for T-B cell cooperation in thymus-dependent (TD) immune response in mammals. However, little is known about its existence and occurrence in lower vertebrates. Here, we report on the identification and functional characterization of CD154 and CD40 homologs from the zebrafish (Danio rerio) model. Zebrafish CD154 is a type II membrane-boun...
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Collagen exposure in tissue activates platelets, initiates wound healing, and modulates adaptive immunity. In this report, data are presented to demonstrate a requirement for platelet-derived CD154 for both collagen-induced augmentation of T-cell immunity and induction of pro-tective immunity to Listeria challenge. Specifically, we demonstrate that Ad5 encoding the membrane-bound form of ovalbu...
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CD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs. Its blockade has been shown to prevent allograft rejection, presumably by interrupting interactions between T cells and APCs. It is known that activated human platelets express and shed CD154 and can induce APC activation and other immune processes in vitro. Here we show that plat...
متن کاملThe inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40.
Recently, we have demonstrated that human platelets carry preformed CD40 ligand (CD154) molecules, which rapidly appear on the platelet surface following stimulation by thrombin. Once on the surface, platelet CD154 induces an inflammatory reaction of CD40-bearing endothelial cells. This study shows that strong platelet agonists other than thrombin also lead to the expression of CD154 on the pla...
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تاریخ انتشار 2008